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Registered Nurse Per Diem Jobs in South Carolina

Advance Your Career with Per Diem RN Jobs in South Carolina

AMN Healthcare, a trusted staffing leader with over 40 years of experience, is dedicated to supporting nursing professionals like you in finding rewarding per diem Registered Nurse opportunities in South Carolina. Each year, we assist more than 10,000 healthcare workers by offering personalized guidance tailored to your career goals. With a wide array of specialties available, including Medical Surgical, Telemetry, Emergency Room, Intensive Care Unit, and many others, you can find the perfect fit to match your skills and interests. Whether you’re passionate about working in Labor & Delivery, Oncology, or Home Health, our extensive network provides a range of roles that offer flexibility and the chance to contribute meaningfully to patient care. Join us at AMN Healthcare and take the next step in your nursing career with the support you deserve.

Explore High Paying Per Diem Registered Nurse Jobs that AMN Healthcare offers in South Carolina

Explore these top-paying jobs currently available in South Carolina:

AMN Healthcare currently has 18 per diem Registered Nurse job opportunities available across South Carolina, offering competitive hourly pay ranging from $33 to $51, with an average of $37 per hour. These positions span specialties like Emergency Room RN, Labor & Delivery Registered Nurse, and Telemetry RN, with opportunities in Rock Hill (14 jobs), Mount Pleasant (3 jobs), and Hilton Head (1 jobs), some of South Carolina’s most in-demand locations.

Whether you’re looking for an immediate start or planning ahead, multiple assignments are available with start dates as early as 12/18/25 (18 jobs). With openings in zip codes like 29732, 29926 and 29464, AMN Healthcare provides access to rewarding travel positions in both urban and suburban settings. If you’re ready to take the next step in your career with a high-paying, flexible travel job in South Carolina, click Apply Now and our expert team will help you find the right fit and guide you through every step of the process.

Recent RN Job Placements in South Carolina

AMN Healthcare has successfully placed 1 Per Diem Registered Nurse professionals in high-demand positions across South Carolina, offering competitive pay and career-enhancing experiences. These previously filled jobs had hourly pay ranging from $51 to $55, with an average of $53, reflecting the strong earning potential for Emergency Room RN, Medical Surgical Registered Nurse, and Telemetry RN professionals.

By reviewing these past placements, you can get a clear picture of the types of opportunities available and the earning potential in Per Diem Registered Nurse positions throughout South Carolina. If you’re ready to explore new assignments with top facilities and competitive pay, AMN Healthcare is here to connect you with the right job and provide expert support throughout your travel career.

Review some of the recently filled Registered Nurse positions in South Carolina and gain insight into the pay rates and opportunities available.

  • CVOR Registered Nurse making $55 per hour filled on 10/9/25

What Types of Facilities and Work Can Registered Nurse Professionals Expect in South Carolina?

South Carolina offers a diverse range of opportunities for Registered Nurses across various healthcare settings, catering to different specialties and preferences. RNs can find rewarding positions in bustling hospitals, community clinics, and rehabilitation centers, providing critical care in fast-paced environments or offering compassionate support in outpatient settings. Additionally, nursing professionals may engage in home health care, delivering personalized services to patients in their residences, or work in long-term care facilities, assisting the elderly and those with chronic conditions. With a growing demand for skilled nursing professionals in areas such as pediatrics, geriatrics, and emergency care, South Carolina’s vibrant healthcare landscape presents abundant opportunities for both career advancement and personal fulfillment.

What Are Some Reasons a RN Professional Should Choose a Per Diem Job in South Carolina?

At AMN Healthcare, we understand that Registered Nurses seeking per diem opportunities in South Carolina can enjoy a perfect blend of professional and personal fulfillment. South Carolina boasts a warm, temperate climate with mild winters and sunny summers, making it an inviting place for outdoor enthusiasts. Vibrant cities like Charleston, with its historic charm, and Greenville, known for its burgeoning arts scene, offer a variety of living experiences. Residents can immerse themselves in the stunning coastal landscapes of the Grand Strand or explore the lush trails of the Blue Ridge Mountains. Additionally, South Carolina is rich in cultural heritage and features activities like visiting charming plantations, savoring world-class Southern cuisine, and enjoying lively music festivals. With flexible per diem roles, RNs not only enhance their careers but also embrace the opportunity to relish life in this beautiful state.

Top Cities in South Carolina with Per Diem Registered Nurse Jobs

AMN Healthcare currently has 18 per diem Registered Nurse jobs in South Carolina. Be sure to check back daily for updates, or if you’re not finding what you’re looking for immediately, sign up for the AMN Passport App and we’ll connect you directly with a recruiter that can help expedite the process of finding your perfect opportunity.
View All Jobs in South Carolina

Highest Paying Jobs in Rock Hill

AMN Healthcare currently has per diem Registered Nurse positions available in Rock Hill.
per diem
Emergency Room Nurse (ER RN)
  • Rock Hill, South Carolina – 29732
  • 12 D,
  • December 18, 2025
$35 to $38
Hourly Pay*
ER RN’s treat patients in emergency situations where they are experiencing trauma or injury. They quickly recognize life-threatening problems and are trained to help solve them on the spot. ER RN’s treat a variety of conditions from sore throats to heart attacks for patients of all ages and backgrounds. They will stabilize patients experiencing trauma and help minimize pain. ER RN’s work in hospital emergency rooms and departments (ER and ED), ambulances, helicopters, urgent care centers, sports arenas, and more. ER’s and hospitals are given a Trauma Rating I-III based upon the kinds of resources available in a trauma center, and the number of patients admitted yearly. Level I is the highest (capable of providing total care for every aspect of injury) and Level III (Level-3) being the lowest. Education/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
*Per Diem Shifts Available  Recent Experience Required.
per diem
Telemetry Nurse (TELE RN)
  • Rock Hill, South Carolina – 29732
  • 12 D,
  • December 18, 2025
$35 to $38
Hourly Pay*
Telemetry RN’s monitor patients’ vital signs by reading and analyzing an electrocardiogram, or another life sign-measuring device. Tele RN’s are required for post-ICU care. Tele RN’s monitor critically ill patients: most are cardiac cases.  Tele RN’s typically work in a hospital setting. Tele RN’s care for patients who are out of the ICU, but need their vital signs monitored closely (after surgery, for example). Education/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
  • ACLS and TELE are often required
*Per Diem Shifts Available  Recent Experience Required.
per diem
Progressive Care Unit Nurse (PCU/SDU RN)
  • Rock Hill, South Carolina – 29732
  • 12 N,
  • December 18, 2025
$35 to $38
Hourly Pay*
PCU RN's closely monitor patients recently released from the ICU before those patients are moved to regular hospital beds. PCU RN’S monitor cardiac and other critical vital signs and detect any changes, thereby enabling intervention of life-threatening, or emergency situations. PCU RN’s work in hospitals, and usually will float as needed to work in Tele or Med Surg units.Education/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
  • ACLS is often required
*Per Diem Shifts Available  Recent Experience Required.
per diem
Progressive Care Unit Nurse (PCU/SDU RN)
  • Rock Hill, South Carolina – 29732
  • 12 D,
  • December 18, 2025
$35 to $38
Hourly Pay*
PCU RN's closely monitor patients recently released from the ICU before those patients are moved to regular hospital beds. PCU RN’S monitor cardiac and other critical vital signs and detect any changes, thereby enabling intervention of life-threatening, or emergency situations. PCU RN’s work in hospitals, and usually will float as needed to work in Tele or Med Surg units.Education/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
  • ACLS is often required
*Per Diem Shifts Available  Recent Experience Required.
View all Jobs in Rock Hill

Highest Paying Jobs in Mount Pleasant

AMN Healthcare currently has per diem Registered Nurse positions available in Mount Pleasant.
per diem Exclusive
Surgical Technician (Surg Tech)
  • Mount Pleasant, South Carolina – 29464
  • 10 D,
  • December 18, 2025
$39 to $42
Hourly Pay*
A ST (often called a scrub tech) works as a part of a surgical team in Operating Rooms as well as in the Labor and Delivery unit. Surg Tech’s provide curtail support to a surgeon such as preparing for surgery, passing instruments, providing needed supplies such as sponges, receiving and containing tissue, and much more.  Surg Tech’s generally work in a hospital and/or outpatient clinic setting. Education/Requirements:
  • High School education is required to obtain a job as a ST, but they can also obtain an optional certification to make them a Certified Surgical Technologist (CST). 
  • To become a CST, they must complete an exam through the National Commission for Certifying Agencies (NBSTSA).
*Per Diem Shifts Available  Recent Experience Required.
per diem Exclusive
Rehabilitation Nurse (Rehab RN)
  • Mount Pleasant, South Carolina – 29464
  • 12 N,
  • December 18, 2025
$35 to $38
Hourly Pay*
A rehabilitation nurse, or rehab nurse, is a nurse who helps patients of any age adjust to chronic illness or injury. The rehab nurse does this by creating care plans, helping educate and assist other caregivers, coordinating care from other healthcare professionals like physical therapists, psychiatrists, speech therapists and occupational therapists. Depending on their workplace, a rehab nurse may be a term for a nurse in any position who specializes in helping rehabilitate patients.Education/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
*Per Diem Shifts Available  Recent Experience Required.
per diem Exclusive
Medical Surgical Nurse (MS RN)
  • Mount Pleasant, South Carolina – 29464
  • 12 N,
  • December 18, 2025
$33 to $36
Hourly Pay*
MS RN's care for adult patients who are acutely ill with a wide variety of medical problems and diseases or are recovering from surgery. Med Surg unit of a facility is where ill patients go to recover before being discharged. They handle large patient loads, juggle multiple patient populations, and adapt to the ever-changing face of nursing care. Although most MS RN's work in the Med Surg unit of hospitals, they can work in a variety of settings includes camps, clinics, schools, and ambulatory care centers.Education/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
  • ACLS occasionally required
*Per Diem Shifts Available  Recent Experience Required.
View all Jobs in Mount Pleasant

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Understanding Per Diem Registered Nurse Job Trends in South Carolina

Understanding the dynamics of the job market is essential for both job seekers and healthcare professionals looking to enhance their career paths. Below, you’ll find a wealth of statistics focused specifically on per diem Registered Nurse positions in South Carolina. These insights reveal average pay trends over the past three months, alongside a comprehensive overview of compensation ranging from minimum to maximum salaries over the last year. This data provides a clear picture of what Registered Nurses can expect in terms of remuneration today.

Additionally, the information showcases the count and types of healthcare facilities across the U.S. that are actively offering Medical Surgical, Telemetry, and Emergency Room roles. By delving into these statistics, you’ll gain valuable knowledge about the current opportunities available, helping you make informed decisions on your next career move. Leverage this data to navigate the evolving landscape of healthcare employment and position yourself for success in a thriving industry.

Salary Range

Jobs by Facility types

Frequently Asked Questions about Per Diem RN Jobs near South Carolina

What is the average pay for a Per Diem RN job in South Carolina?

The average hourly pay for a Per Diem Registered Nurse job in South Carolina is $38, based on 19 jobs as of December 4, 2025.

What is the highest hourly pay for a Per Diem Registered Nurse job in South Carolina?

Based on 19 recent jobs, the highest hourly pay for a Per Diem Registered Nurse job in South Carolina is $55, working in Progressive Care Unit, as of December 4, 2025.

What types of experience are most commonly required for a Per Diem Registered Nurse job in South Carolina?

Most per diem Registered Nurse positions in South Carolina require a valid nursing license and relevant clinical experience in areas such as medical-surgical, emergency, or critical care. Additionally, familiarity with electronic health records and the ability to adapt quickly to different healthcare settings are often essential.

What types of job opportunities are typically available for RN Per Diem positions in South Carolina?

Registered Nurse opportunities in South Carolina encompass Travel, Per Diem, and Rapid Response positions. These roles offer adaptable work arrangements, allowing professionals to choose options that align with their career goals, lifestyle, and level of experience.

What types of healthcare facilities in South Carolina typically offer Per Diem positions for Registered Nurse professionals?

In South Carolina, per diem positions for Registered Nurse professionals are commonly found in hospitals, long-term care facilities, and outpatient clinics. These settings often require flexible staffing to accommodate varying patient needs and ensure quality care.

What types of specialties are common for a Registered Nurse professional working a Per Diem job in South Carolina?

In South Carolina, per diem Registered Nurses commonly work in specialties such as emergency care, critical care, and surgical services, reflecting the diverse needs of healthcare facilities. Many also find opportunities in maternal and pediatric care, as well as in outpatient clinics. Flexibility and adaptability are essential traits for per diem nurses, as they may fill various roles depending on facility requirements. This variety allows them to gain experience across multiple areas of healthcare.

What are some keys reasons a Per Diem Registered Nurse professional might consider seeking a Medical Surgical, Telemetry, and Emergency Room job in South Carolina?

A per diem Registered Nurse might seek positions in Medical Surgical, Telemetry, and Emergency Rooms in South Carolina due to the state’s growing healthcare demand and favorable work-life balance opportunities. Additionally, the diverse patient population and seasonal tourism can provide enriching experiences and the chance to enhance clinical skills.

What are some most popular cities in South Carolina a Per Diem RN professionals would prefer to work and live?

Some of the most popular cities in South Carolina for per diem Registered Nurse professionals include Charleston, Greenville, and Columbia. These cities not only offer a diverse range of healthcare facilities but also provide a vibrant culture and amenities that attract nursing professionals. Additionally, their growing economies and favorable living conditions contribute to their appeal.

What important factors should a Per Diem Registered Nurse professional consider when evaluating a new position in Medical Surgical, Telemetry, and Emergency Room in South Carolina?

When evaluating a new position as a per diem Registered Nurse in South Carolina, professionals should consider the pay rate and benefits, the flexibility of scheduling, and the work environment of the facility. Additionally, understanding the local demand for nursing services and any potential impact on job stability is crucial. Ensuring the position aligns with their career goals and preferred patient demographic will also play a significant role in their decision.

Which South Carolina Cities Offer Job Opportunities for Registered Nurse Professionals?

South Carolina offers a vibrant landscape for Registered Nurses specializing in Medical Surgical, Telemetry, and Emergency Room care, with several cities boasting diverse job opportunities, competitive salaries, and an appealing lifestyle. Rock Hill, Mount Pleasant, and Hilton Head Island are three exceptional locations where AMN Healthcare is currently seeking talented nursing professionals ready to make a difference in their communities while enjoying all the benefits these cities have to offer.

Rock Hill, located just south of Charlotte, North Carolina, combines the charm of a small town with the conveniences of nearby urban areas. Registered Nurses here can expect to earn between $1,406 and $1,510 per week, which translates to a solid income against a relatively low cost of living. The housing market is accommodating, with options ranging from quaint cottages to modern apartments, making it easy for nurses to find the ideal home. The city’s lively cultural scene and numerous outdoor recreational opportunities, including parks and the picturesque Catawba River, provide a great work-life balance amidst a welcoming community atmosphere.

In picturesque Mount Pleasant, a thriving suburb of Charleston, the opportunities for Registered Nurses are not only plentiful but also financially rewarding, with weekly salaries ranging from $1,330 to $1,673. The cost of living is slightly higher than in Rock Hill, yet Mount Pleasant offers a plethora of housing options, from waterfront properties to bustling neighborhoods, allowing for a diverse selection depending on personal preferences. With its proximity to stunning beaches, historic sites, and outdoor activities such as boating and biking, Mount Pleasant caters to an active lifestyle alongside a supportive work environment. The blend of southern charm and modern amenities makes it a desirable place for healthcare professionals.

Hilton Head Island stands out as a premier destination for Registered Nurses, not only for its breathtaking scenic beauty but also for its competitive pay range of $1,900 to $2,203 per week, which significantly enhances one’s financial stability. Although the cost of living tends to be higher than in Rock Hill and Mount Pleasant, the island offers stunning oceanfront views and luxurious living arrangements, from ocean-view condos to charming beach houses. The island’s mild climate, characterized by warm summers and mild winters, creates ideal conditions for year-round outdoor activities such as golfing, boating, and exploring nature reserves. Living in Hilton Head means embracing a lifestyle filled with leisure and adventure while working in a supportive healthcare environment.

Together, these cities in South Carolina present registered nurses with unique professional opportunities and lifestyles. Whether it’s the small-town charm of Rock Hill, the coastal allure of Mount Pleasant, or the luxurious atmosphere of Hilton Head Island, nursing professionals will find fulfilling careers and vibrant living conditions that contribute to a fulfilling life both on and off the clock.

Discover Healthcare Facilities in South Carolina That Hire Registered Nurse Professionals

In South Carolina, our esteemed healthcare facilities have a proven track record of employing Registered Nursing professionals in per diem roles across Medical Surgical, Telemetry, and Emergency Room settings. These organizations not only provide flexible job opportunities but also prioritize career growth and advancement for nurses eager to elevate their expertise in dynamic clinical environments.

East Cooper Medical Center
Shifts
8 E, 10 D, 12 D, and 12 N
Job Durations
1 wks, 12 wks, 13 wks, and 14 wks
Address
2000 Hospital Dr
Mount Pleasant, SC 29464
Nearby Neighborhoods
Parish Place (29465), Point Pleasant (29465), Wando Estates (29413), Somerset Point (29413), Hickory Shadows (29465)
Bon Secours St. Francis Downtown (Simplify)
Shifts
8 D, 8 E, 10 D, 12 D, 12 E, and 12 N
Job Durations
12 wks and 13 wks
Departments
Cardiovascular ICU Registered Nurse, Cardiovascular Operating Room Registered Nurse, Cardiovascular Operating Room Surgical Technologist, Cardiovascular Operating Room Surgical Technology, CVOR Surgical First Assist Nursing, First Assist Registered Nurse, First Assist Surgical Technology, First Assist Surgical Technology, First Assist Surgical Technology Nursing, First Assist Surgical Technology Nursing, Operating Room RN, and OR Surgical First Assist Nursing
Address
1 Saint Francis Dr
Greenville, SC 29601
Nearby Neighborhoods
University Ridge Homes (29601), Boyce Lawn (29616), Mountain View Homes (29601), Alta Vista (29603), Roosevelt Heights (29603)
McLeod Health Cheraw (FKA: Chesterfield General Hospital)
Shifts
8 D, 10 D, 12 D, and 12 N
Job Durations
13 wks
Address
711 CHESTERFIELD HWY.
Cheraw, SC 29520
* Estimate of payments is intended for informational purposes and includes hourly wages, as well as reimbursements for meal & incidental expenses and housing expenses incurred on behalf of the Company. Please speak with a recruiter for additional details.