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Medical Surgical Registered Nurse Per Diem Nursing Jobs South Carolina for RNs

Learn More About Per Diem Opportunities in Medical Surgical RN in South Carolina

At AMN Healthcare, we understand the unique needs of Medical Surgical RNs seeking per diem opportunities in South Carolina, and with over 40 years as a staffing leader, we are committed to connecting you with rewarding positions that fit your lifestyle and professional goals. Every year, we support more than 10,000 healthcare workers, providing personalized guidance to ensure that your career path is aligned with your aspirations. By partnering with AMN Healthcare, you gain access to a wide range of per diem job openings that not only offer flexibility but also allow you to make a meaningful impact in patient care. Let us help you navigate your nursing career and find the perfect opportunity that suits your expertise and availability.

Explore Top Medical Surgical RN Jobs in South Carolina with Flexible Opportunities at AMN Healthcare

Check out the top-paying Medical Surgical Registered Nurse job currently available in South Carolina:

At AMN Healthcare, we currently have 1 Per Diem Medical Surgical RN job opportunity available across Short Term Acute Care Hospital (1 job) in South Carolina, offering competitive hourly pay ranging from $33 to $36, with an average of $34 per hour.

Our job openings are located in multiple zip codes, including 29732 and 29464, with flexible start dates on 11/08/26 (1 job), ensuring that you can find the right fit for your schedule and career goals.

If you’re ready to take the next step, simply click Apply Now, and we’ll connect you with a recruiter for tailored support!

Learn More about Hiring Trends for Medical Surgical RNs in South Carolina

At AMN Healthcare, we have successfully placed 2 Medical Surgical RNs in high-paying Per Diem jobs across South Carolina, helping professionals like you find rewarding opportunities in top healthcare facilities. These recently filled positions offered hourly pay ranging from $35 to $38, with an average of $36 per hour. Job placements spanned multiple cities around South Carolina including Rock Hill ensuring flexibility and a variety of work environments.

Our previously filled roles were at respected healthcare institutions such as Piedmont Medical Center, demonstrating the wide range of opportunities available for skilled professionals like you. If you’re looking for similar Per Diem job openings in South Carolina, now is the perfect time to explore your options. With our industry expertise and personalized job-matching services, AMN Healthcare can help you find your ideal position with competitive pay and great benefits.

Take a look at some of the latest Medical Surgical RN positions recently filled in South Carolina, offering insight into the competitive pay rates and exciting opportunities available.

  • Medical Surgical RN making $38 per hour filled on 10/2/26
  • Medical Surgical RN making $38 per hour filled on 5/14/26

Where Can a Medical Surgical RN Work in South Carolina and What Can They Expect?

As a Medical Surgical RN in South Carolina, you can expect to find rewarding opportunities across a variety of healthcare settings, including bustling community hospitals, specialized surgical centers, and long-term acute care facilities. Your role will involve providing comprehensive patient care, monitoring vital signs, managing post-operative recovery, and collaborating with a multidisciplinary team to ensure optimal patient outcomes. Whether you’re working in a scenic coastal town or a vibrant city like Charleston or Columbia, you’ll engage with diverse patient populations, enhancing your clinical skills while contributing to the health and well-being of the community. With the increasing demand for healthcare services in the region, South Carolina offers a robust job market, allowing for flexibility in shifts and the potential for career advancement in both clinical and administrative pathways.

Why Should Medical Surgical RNs Consider a Per Diem Job in South Carolina?

As a Medical Surgical RN considering a per diem job in South Carolina, you’ll be delighted by the state’s blend of professional flexibility and vibrant lifestyle. South Carolina offers a mild climate year-round, with warm summers and mild winters, making it an ideal place for outdoor enthusiasts and those who enjoy a variety of recreational activities. Cities like Charleston, with its historic charm and waterfront views, and Greenville, known for its thriving arts scene and beautiful parks, provide a dynamic living environment. While working per diem, you’ll have the opportunity to explore the stunning beaches of the Lowcountry, hike in the Blue Ridge Mountains, or indulge in the state’s renowned cuisine, including delightful Southern barbecue and seafood. This unique combination of a fulfilling job, rich culture, and diverse landscapes makes South Carolina an attractive option for those seeking both professional growth and a vibrant lifestyle.

Top Cities in South Carolina with Per Diem Medical Surgical Registered Nurse Jobs

AMN Healthcare currently has 1 per diem Medical Surgical RN job in South Carolina and 83 nationwide. Be sure to check back daily for updates, or if you’re not finding what you’re looking for immediately, sign up for the AMN Passport App and we’ll connect you directly with a recruiter that can help expedite the process of finding your perfect opportunity.

View All Jobs in South Carolina

Highest Paying Medical Surgical RN Jobs in Mount Pleasant, SC

AMN Healthcare currently has per diem Medical Surgical Registered Nurse positions available in Mount Pleasant.
per diem Exclusive
Medical Surgical Nurse (MS RN)
  • Mount Pleasant, South Carolina – 29464
  • 12 N,
  • November 8, 2026
$33 to $36
Hourly Pay*
MS RN's care for adult patients who are acutely ill with a wide variety of medical problems and diseases or are recovering from surgery. Med Surg unit of a facility is where ill patients go to recover before being discharged. They handle large patient loads, juggle multiple patient populations, and adapt to the ever-changing face of nursing care. Although most MS RN's work in the Med Surg unit of hospitals, they can work in a variety of settings includes camps, clinics, schools, and ambulatory care centers.Education/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
  • ACLS occasionally required
*Per Diem Shifts Available  Recent Experience Required.
View all Jobs in Mount Pleasant, SC

Highest Paying Medical Surgical RN Jobs in Dublin, GA

AMN Healthcare currently has per diem Medical Surgical Registered Nurse positions available in Dublin.
per diem
Medical Surgical Nurse (MS RN)
  • Dublin, Georgia – 31021
  • 12 D,
  • November 8, 2026
$37 to $40
Hourly Pay*
MS RN’s care for adult patients who are acutely ill with a wide variety of medical problems and diseases or are recovering from surgery. Med Surg unit of a facility is where ill patients go to recover before being discharged. They handle large patient loads, juggle multiple patient populations, and adapt to the ever-changing face of nursing care. Although most MS RN’s work in the Med Surg unit of hospitals, they can work in a variety of settings includes camps, clinics, schools, and ambulatory care centers.Education/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
  • ACLS occasionally required
View all Jobs in Dublin, GA

Highest Paying Medical Surgical RN Jobs in Somerset, KY

AMN Healthcare currently has per diem Medical Surgical Registered Nurse positions available in Somerset.
per diem Exclusive
Medical Surgical Nurse (MS RN)
  • Somerset, Kentucky – 42503
  • 12 D,
  • November 8, 2026
$39 to $42
Hourly Pay*
MS RN’s care for adult patients who are acutely ill with a wide variety of medical problems and diseases or are recovering from surgery. Med Surg unit of a facility is where ill patients go to recover before being discharged. They handle large patient loads, juggle multiple patient populations, and adapt to the ever-changing face of nursing care. Although most MS RN’s work in the Med Surg unit of hospitals, they can work in a variety of settings includes camps, clinics, schools, and ambulatory care centers.Education/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
  • ACLS occasionally required
View all Jobs in Somerset, KY

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Insights into Per Diem Medical Surgical RN Job Trends in South Carolina

As you explore the dynamic landscape of per diem Medical Surgical Registered Nurse jobs in South Carolina, the following data provides invaluable insights into the current job market. With average pay trends tracked over the past three months, you’ll gain a clear understanding of how compensation is evolving. Additionally, the data reflects the average, minimum, and maximum pay for these positions over the last year, helping you to gauge what to expect and negotiate as you navigate your career path.

Moreover, the information detailing the count and types of healthcare facilities across the U.S. reveals the abundance of opportunities available to skilled professionals like you. By leveraging this data, you can make informed decisions about your next career move, whether you’re entering the workforce or seeking new challenges. Stay ahead of the curve and use these insights to enhance your understanding of the per diem nursing job market.

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Frequently Asked Questions about Per Diem Medical Surgical RN Jobs near South Carolina

How much does a Per Diem Medical Surgical RN earn in South Carolina on average?

As of October 25, 2026 the average hourly pay for a Per Diem Medical Surgical RN in South Carolina is $35.

What is the highest salary offered for a Medical Surgical Registered Nurse Per Diem job in South Carolina?

As of October 25, 2026, the highest hourly pay for a per diem Medical Surgical RN job in South Carolina is $38.

What types of experience are often expected for an MS Per Diem job in South Carolina?

For a MS (Management Systems) job in South Carolina, experience with project management, systems analysis, and proficiency in relevant software tools is often required. Additionally, a background in data analytics and previous roles in team leadership can enhance a candidate’s attractiveness to potential employers.

What job opportunities are typically available for Medical Surgical RN per diem positions in SC?

Medical Surgical Registered Nurse positions in South Carolina include Per Diem roles. These options provide flexibility for professionals seeking different work arrangements based on their preferences and experience.

What types of facilities typically hire Medical Surgical Registered Nurse Per Diem jobs in South Carolina?

Medical Surgical per diem jobs in South Carolina are typically available in hospitals, outpatient centers, and rehabilitation facilities. These roles often provide flexible scheduling for nurses to support patient care across various units.

Which work shifts are typically offered for MS per diem jobs in South Carolina?

Typical work shifts offered for per diem MS positions in South Carolina include 12 N and 12 D shifts. These options provide flexibility to accommodate different scheduling preferences.

What kinds of benefits from an employer should a Medical Surgical RN look for when looking for a Per Diem job in South Carolina?

When seeking a per diem job in South Carolina, it’s important to look for benefits that enhance job satisfaction and financial security. Employers that offer flexible scheduling can greatly accommodate personal commitments, making the role more manageable. Additionally, consider whether the company provides any form of health benefits, even on a per diem basis, like access to employee assistance programs or health insurance options. Other valuable offerings might include professional development opportunities and reimbursement for travel expenses, which can significantly impact overall job experience.

What are some top reasons a Per Diem Medical Surgical RN would have for looking for a job in South Carolina?

A per diem worker may seek a job in South Carolina for the state’s growing healthcare industry and diverse job opportunities in various sectors, offering flexibility and potential career growth. Additionally, the lower cost of living and pleasant climate could be attractive incentives for relocation.

What are some most popular cities in South Carolina a Per Diem Medical Surgical RN would want to work and live in?

Some of the most popular cities in South Carolina for a per diem worker to live and work include Charleston, known for its historic charm and vibrant culture, and Columbia, the state capital, which offers a mix of urban amenities and outdoor recreation. Greenville is also a notable choice, with a thriving downtown and a strong sense of community. Each of these cities provides unique opportunities and a quality lifestyle that makes them appealing.

What things should a Per Diem Medical Surgical RN look for in a new position?

A per diem should look for flexibility in scheduling to accommodate personal commitments and preferences, as well as competitive pay rates that reflect their skills and experience. It’s also important to consider the work environment and team dynamics to ensure a supportive atmosphere. Lastly, the opportunity for skill development and advancement can enhance long-term career satisfaction.

Which Cities in South Carolina Offer the Best Medical Surgical RN Job Opportunities?

For medical professionals seeking vibrant communities to advance their careers, Rock Hill and Mount Pleasant in South Carolina offer enticing job opportunities for Medical Surgical Registered Nurses. With their unique charms, competitive pay, and a supportive environment, these cities provide an excellent backdrop for both personal and professional growth.

Rock Hill, located just south of Charlotte, NC, offers an impressive weekly salary for Medical Surgical RNs, ranging from $1,406 to $1,510. The cost of living in Rock Hill is relatively affordable compared to many urban areas, allowing nurses to enjoy a comfortable lifestyle without financial strain. Housing options in the city are diverse, including single-family homes, townhouses, and apartments, catering to various preferences and budgets. The work environment in Rock Hill is bolstered by a sense of community and collaboration among healthcare professionals, which can be incredibly rewarding. With a mild climate featuring four distinct seasons, residents can enjoy outdoor activities year-round, from hiking in nearby parks to exploring local festivals and events that showcase the city’s rich history.

Mount Pleasant, situated near the picturesque coastline, presents a pay range for Medical Surgical RNs between $1,330 and $1,428 per week. This charming town not only offers a competitive salary but also boasts a cost of living that is higher than the national average, yet the quality of life is undeniably appealing. The housing market includes a mix of luxury waterfront homes, historic properties, and modern apartments, providing options for various lifestyles. The healthcare facilities in Mount Pleasant foster a collaborative and dynamic work environment, encouraging professional growth and development. Additionally, the coastal climate brings warm, sunny days perfect for exploring the nearby beaches, historic sites, and a vibrant culinary scene that epitomizes Southern charm, making it an ideal location for those who value a balanced lifestyle.

Both Rock Hill and Mount Pleasant represent excellent opportunities for Medical Surgical Registered Nurses looking to embark on a fulfilling journey in South Carolina. With competitive salaries, diverse housing options, supportive work environments, and a wealth of lifestyle activities, these cities promise not just a job but a rich experience filled with personal and professional growth. Whether drawn by the local history, the beautiful landscapes, or the promise of community, healthcare professionals will find that their next great adventure awaits in these welcoming cities.

Discover Healthcare Facilities in South Carolina That Hire Medical Surgical Registered Nurse Professionals

In South Carolina, a diverse array of healthcare facilities has consistently embraced the expertise of Medical Surgical Registered Nurses for per diem positions, offering flexible opportunities for those seeking to enhance their careers while making a meaningful impact in patient care. From bustling hospitals to specialized clinics, these institutions understand the invaluable role of skilled nursing professionals in delivering quality healthcare and maintaining positive patient outcomes.

East Cooper Medical Center
TJC
For-Profit
East Cooper Medical Center is a short-term acute care hospital at 2000 Hospital Dr in Mount Pleasant, SC, near Parish Place and Point Pleasant; established in 1986, it is a for-profit institution accredited by TJC. The facility has 140 beds, 10 operating rooms, a cardiac catheterization lab, four endoscopy rooms and a broad inpatient footprint that includes a designated trauma center, NICU and neonatal nursery, CCU, burn unit, multiple ICU types (medical/surgical and surgical), CARF inpatient rehabilitation and both inpatient and outpatient psychiatric services. Clinical offerings span advanced imaging and diagnostic services (CT, MRI, PET, nuclear medicine), perioperative and surgical subspecialties (open heart/cardiothoracic, neurosurgical, orthopedic, ophthalmic, reconstructive), acute renal dialysis and a range of therapy services and outpatient care. Employed professions include nursing, physicians, allied health, support services and advanced practice providers; the center hosts multiple residency program types (allopathic, osteopathic, dental, podiatric and other) and operates with a workforce equivalent to approximately 380 full-time positions.
2000 Hospital Dr, Mount Pleasant, SC 29464
140 certified beds 10 operating rooms Established 1986
SERVICES
Pharmacy
Acute Renal Dialysis
Alcohol/Drug
Anesthesia
Audiology
Departments
Sterile Processor, OR, ER, Labor & Delivery, Postpartum, MS, Rehab, Adult Inpatient Psychiatric, Burn Care Unit, Cardiac Catheterization Lab, Open Heart / Cardiothoracic Surgery, CARF Inpatient Rehabilitation, Coronary Care Unit (CCU), Designated Trauma Center, Emergency Department, Emergency Psychiatric, Forensic Psychiatric, Geriatric Psychiatric, Gerontological Specialty, Inpatient Surgical, Intensive Care Unit (Medical/Surgical ICU), Medicare Certified Transplant Center, Neonatal ICU (NICU), Neonatal Nursery, Neurosurgical, Organ Transplant (Non-Medicare Certified), Obstetrics (OB/L&D), Ophthalmic Surgery, Orthopedic Surgery (Hospital), Outpatient Psychiatric, Outpatient Rehabilitation, Outpatient Surgery, Pediatric, Pediatric ICU, Child/Adolescent Psychiatric, Reconstructive Surgery, Surgical ICU, Urgent Care Center, and Rehabilitation Unit
Shifts: 8 E, 10 D, 12 D, 12 E, and 12 N
Durations: 1 wks and 13 wks
Hilton Head Hospital
Hilton Head Hospital is a short-term acute care hospital located at 25 Hospital Center Blvd, Hilton Head Island, SC. Its clinical departments include a broad mix of surgical and perioperative services (OR, CVOR, PACU, sterile processing), emergency care and critical care units (ER, ICU, PCU, NICU), maternal and pediatric services (Labor & Delivery, postpartum, pediatrics), and diagnostic services such as laboratory, computed tomography, nuclear medicine and echocardiography, with additional specialties including vascular and medical-surgical units. The facility employs physicians, advanced practice providers, nursing staff and allied health professionals.
25 Hospital Center Blvd, Hilton Head Island, SC 29926
Departments
Laboratory, OR, Sterile Processor, PCU, ICU, PACU, Postpartum, Acute, Computed Tomography, MS, Labor & Delivery, Pedi, Nuclear Medicine, CVOR, NICU, Adult, ER, Echo, and Vascular
Shifts: 8 D, 10 D, 10 E, 10 N, 12 D, 12 E, and 12 N
Durations: 6 wks, 8 wks, 12 wks, 13 wks, 14 wks, 26 wks, and 118 wks
McLeod Regional Medical Center
McLeod Regional Medical Center is a short-term acute care hospital at 555 E Cheves St in Florence, SC, located near the Wilson Heights and Woodmont neighborhoods. Departments include OR and CVOR, Cath Lab and vascular services, MS along with adult and acute care units, radiology and mammography, and labor & delivery. The facility’s clinical staff includes allied health professionals and nursing personnel.
555 E Cheves St, Florence, SC 29506
Departments
OR, MS, Radiology, Acute, Vascular, Labor & Delivery, Cath Lab, CVOR, Mammography, and Adult
Shifts: 8 D, 10 D, 12 D, 12 E, and 12 N
Durations: 4 wks, 9 wks, 12 wks, and 13 wks
Piedmont Medical Center
Piedmont Medical Center is a short-term acute care hospital located at 222 South Herlong Ave in Rock Hill, SC, near Botany Woods and Greenfield Acres. Clinical departments span surgical and procedural areas (OR, CVOR, Ambulatory PACU), cardiac services including a cath lab and CVICU, multiple critical care units (ICU, PCU, telemetry), maternal/child services (Labor & Delivery, NICU, pediatrics), an emergency department, and advanced imaging such as CT and MRI. The facility’s clinical workforce includes allied health professionals, physicians, and nursing staff.
222 South Herlong Ave, ROCK HILL, SC 29732
Departments
PCU, CVOR, CVICU, Magnetic Resonance Imaging, Cath Lab, NICU, ICU, Labor & Delivery, ER, Computed Tomography, OR, Telemetry, Adult, Pedi, MS, and Ambulatory PACU
Shifts: 8 D, 10 D, 12 D, 12 E, and 12 N
Durations: 2 wks, 8 wks, 9 wks, 12 wks, 13 wks, and 14 wks
Trident Medical Center
TJC
For-Profit
Trident Medical Center is a short-term acute care hospital located at 9330 Medical Plaza Dr in Charleston, SC, near the Huntington Woods and Parkshire neighborhoods; it was established in 1975, is for-profit, has 497 beds and is accredited by TJC. Clinical capacity includes 22 operating rooms, two cardiac catheterization labs, six endoscopy rooms and a wide range of diagnostic and therapeutic services such as CT, MRI, PET, nuclear medicine, extracorporeal shockwave lithotripsy, dialysis and comprehensive perioperative and rehabilitation services. Departments span emergency and designated trauma services, multiple critical care units (CVICU, CCU, medical/surgical ICU, pediatric ICU), obstetrics and neonatal nursery, cardiothoracic and vascular surgery, interventional and diagnostic radiology, inpatient and outpatient psychiatry, burn care and CARF inpatient rehabilitation, among others. The medical staff includes physicians, advanced practice providers, nursing, allied health and support services, the facility hosts allopathic, osteopathic, dental, podiatric and other residency programs, and operates with a workforce equivalent to approximately 2,217 full-time positions.
9330 Medical Plaza Dr, CHARLESTON, SC 29406
497 certified beds 22 operating rooms Established 1975
SERVICES
Pharmacy
Acute Renal Dialysis
Anesthesia
Audiology
Chemotherapy
Departments
Telemetry, CVICU, MS, Nuclear Medicine, Trauma, Critical Care, Diagnostic, Rehab, EEG, OR, CVOR, Vascular, Psych, Acute, PACU, Computed Tomography, Echo, EP Lab, PCU, Positron Emission Tomography, Cath Lab, Case Manager, Dialysis, Magnetic Resonance Imaging, OB/GYN, Surgical, Radiology, ICU, Interventional Radiology, Hospitalist, Adult Inpatient Psychiatric, Burn Care Unit, Cardiac Catheterization Lab, Open Heart / Cardiothoracic Surgery, CARF Inpatient Rehabilitation, Coronary Care Unit (CCU), Designated Trauma Center, Emergency Department, Emergency Psychiatric, Gerontological Specialty, Inpatient Surgical, Intensive Care Unit (Medical/Surgical ICU), Neonatal Nursery, Neurosurgical, Obstetrics (OB/L&D), Orthopedic Surgery (Hospital), Outpatient Psychiatric, Outpatient Rehabilitation, Outpatient Surgery, Pediatric, Pediatric ICU, Reconstructive Surgery, Surgical ICU, Psychiatric Unit, and Rehabilitation Unit
Shifts: 8 D, 8 E, 8 N, 9 D, 10 D, 10 E, 10 N, 12 D, 12 E, and 12 N
Durations: 6 wks, 8 wks, 11 wks, 12 wks, 13 wks, 15 wks, and 26 wks
* Estimate of payments is intended for informational purposes and includes hourly wages, as well as reimbursements for meal & incidental expenses and housing expenses incurred on behalf of the Company. Please speak with a recruiter for additional details.