Discover our exclusive selection of per diem Medical Surgical Registered Nurse positions in Sioux Falls, South Dakota, designed for healthcare professionals seeking both flexibility and lucrative opportunities. These roles represent the highest-paying Medical Surgical RN jobs currently offered by AMN Healthcare, allowing you to maximize your earnings while delivering essential care to patients. Whether you’re looking to enhance your experience or simply seeking to boost your income, these top-tier positions ensure you can enjoy the benefits of per diem work within a vibrant healthcare community. Explore the listings below to find the perfect fit for your career aspirations!
At AMN Healthcare, we understand the unique needs of nursing professionals, especially those seeking per diem Medical Surgical jobs in Sioux Falls. With over 40 years of experience as a staffing leader, we proudly support more than 10,000 healthcare workers each year, providing them with access to exceptional job opportunities tailored to their skills and preferences. Our commitment to personalized guidance ensures that you receive tailored support throughout your career, helping you navigate your professional journey with confidence. Join our team of dedicated Medical Surgical RNs and empower your nursing career with the flexibility and opportunities that AMN Healthcare uniquely offers.
Here are some of the highest paying Medical Surgical RN jobs currently available in Sioux Falls, South Dakota:
AMN Healthcare currently has 2 Medical Surgical Registered Nurse jobs available in Sioux Falls, with start dates as early as 12/18/25. As of December 4, 2025, the average hourly pay for a Medical Surgical RN in Sioux Falls was $36, with the range in pay between $35 and $38.
If Sioux Falls isn’t your only option, we also have Medical Surgical Registered Nurse jobs nearby in Pierre (190.1 miles), Osseo (195.7 miles) and Wichita (406.1 miles). Or, if you’re looking for cities with the largest variety of Medical Surgical Registered Nurse jobs available currently, you should try Osseo (8 jobs), Tucson (8 jobs), Denver (7 jobs), New York City (6 jobs), and Ocala (4 jobs).
If you’re interested, just Apply Now and we’ll match you with a recruiter for more personalized service!
As a Medical Surgical RN in Sioux Falls, South Dakota, you can anticipate a diverse and fulfilling range of responsibilities across various healthcare facilities, including community hospitals, regional medical centers, and outpatient clinics. In these settings, you’ll be integral to patient care teams, managing post-operative patients, administering medications, and monitoring vital signs, while collaborating closely with physicians and other healthcare professionals to develop care plans. Sioux Falls, known for its vibrant healthcare landscape, offers opportunities in facilities such as Avera McKennan Hospital and Sanford USD Medical Center, where advanced technology and supportive environments foster professional growth. Additionally, you might engage in patient education, discharge planning, and support for chronic illness management, all contributing to the well-being of the community you serve.
As a Medical Surgical RN considering a per diem opportunity in Sioux Falls, South Dakota, you’ll find not only a rewarding work environment but also an appealing lifestyle that combines charm and convenience. Sioux Falls boasts a lower cost of living compared to many urban areas, allowing you to save while enjoying a plethora of outdoor activities, from exploring the stunning Falls Park to hiking in the nearby Lewis and Clark Recreation Area. The weather offers a distinct four-season experience, with vibrant autumns and mild summers perfect for outdoor festivals. Popular neighborhoods like the Historic District and downtown Sioux Falls not only provide a unique blend of local boutiques and dining but also foster a strong sense of community. Plus, the local arts scene, including the perfect balance of galleries, theaters, and live music venues, ensures that there’s always something fun to do when you’re off the clock. Embrace the opportunity to enhance your career while enjoying a fulfilling lifestyle in Sioux Falls!
Explore our exciting opportunities for per diem Medical Surgical Registered Nurse positions available in Sioux Falls, where you can make a meaningful impact in patient care. Take a moment to browse through the listings below and find the ideal job that aligns with your skills and career goals!
As you navigate the dynamic healthcare job market in Sioux Falls, it’s essential to arm yourself with the right information. Below, you’ll find a comprehensive set of statistics specifically for per diem Medical Surgical Registered Nurse positions. These charts provide valuable insights into average pay trends over the past three months, as well as a detailed overview of compensation—highlighting the average, minimum, and maximum salaries for the last year. By analyzing these figures, you can better assess your earning potential and negotiate confidently.
Additionally, you’ll discover important data on the types and counts of healthcare facilities in Sioux Falls that are actively seeking qualified RNs. Understanding the landscape of available jobs not only helps you make informed career decisions but also enables you to target your job search more effectively. We encourage you to leverage this information as you explore the vibrant opportunities that await you in Sioux Falls.
Most per diem Medical Surgical Registered Nurse positions in Sioux Falls require candidates to have a valid RN license in South Dakota along with experience in a clinical setting, particularly in acute care or surgical environments. Additionally, preferred qualifications often include certifications in Basic Life Support (BLS) and Advanced Cardiac Life Support (ACLS), as well as a demonstrated ability to work effectively in a fast-paced, team-oriented atmosphere.
Medical Surgical Registered Nurse per diem jobs in Sioux Falls, South Dakota, are typically offered by hospitals, urgent care centers, and outpatient clinics. These facilities seek flexible nursing staff to assist with various patient care needs in dynamic environments.
When seeking a per diem job as a Medical Surgical RN in Sioux Falls, South Dakota, it’s important to inquire about flexible scheduling options that accommodate personal needs, as well as competitive pay rates that reflect your experience and expertise. Additionally, ask about available benefits such as continuing education support and access to resources for mental and emotional well-being, which can greatly enhance your work experience.
A per diem Medical Surgical RN might seek a job in Sioux Falls due to the city’s growing healthcare facilities and opportunities for flexible work schedules, which allow for better work-life balance. Additionally, Sioux Falls offers a supportive community and a lower cost of living compared to larger metropolitan areas, making it an attractive location for healthcare professionals.
Some popular neighborhoods in Sioux Falls for a per diem Medical Surgical RN include Downtown Sioux Falls, known for its vibrant atmosphere and convenient access to various amenities, and the historic district of the McKennan Park area, which offers beautiful homes and proximity to local parks and hospitals. Additionally, the Southeast neighborhood is appealing for its family-friendly environment and nearby healthcare facilities. Each of these areas provides a unique blend of community feel and accessibility to work opportunities.
A per diem Medical Surgical RN should look for a supportive team environment that fosters collaboration and communication, as well as flexible scheduling that accommodates their personal needs. It’s also essential to consider the hospital’s reputation for patient care and the availability of resources that enhance both the RN’s professional development and the quality of care delivered. Additionally, competitive pay and benefits, even for per diem roles, are important factors that can influence job satisfaction.
One city that shares similarities with Sioux Falls, South Dakota, is Rapid City, South Dakota. Rapid City boasts a similar cost of living, making it an attractive option for Medical Surgical RNs seeking affordability in housing and everyday expenses. The climate is also comparable, with cold winters and warm summers, creating a familiar weather pattern for those accustomed to Sioux Falls. Additionally, Rapid City provides a vibrant community atmosphere with numerous outdoor activities, including access to the Black Hills and Mount Rushmore, promoting an active lifestyle.
Another viable option is Fargo, North Dakota, which features job opportunities in healthcare that parallel those found in Sioux Falls. The pay range for Medical Surgical RNs in Fargo is quite competitive, and, like Sioux Falls, it offers a reasonable cost of living, allowing for a strong purchasing power in housing markets. The climate mirrors that of Sioux Falls with cold winters and temperate summers, and the city has numerous recreational activities, including parks and cultural attractions, fostering a well-rounded lifestyle for residents.
Minot, North Dakota, presents similar characteristics to Sioux Falls as well, especially in terms of job availability in the nursing sector. The pay scale for RNs is comparable, and the housing market is often accessible, making it feasible for new graduates or experienced nurses alike. With a climate that features harsh winters and warm summers, Minot offers a familiar environment. The community is tight-knit, with a slower pace of life and plenty of outdoor recreational opportunities, contributing to a fulfilling lifestyle for those who enjoy nature and small-town charm.
Little Rock, Arkansas, is also a comparable city, offering a growing healthcare sector that includes demand for Medical Surgical RNs. While the climate differs, being milder with a more humid subtropical weather pattern, it presents a low cost of living and affordable housing options similar to Sioux Falls. The local lifestyle includes access to cultural events, festivals, and outdoor activities along the Arkansas River, balancing both professional and personal enjoyment without the fast pace often associated with larger metropolitan areas.
Lastly, Lansing, Michigan, provides an intriguing alternative with a stable healthcare job market suitable for Medical Surgical RNs. Pay ranges may be slightly lower than in Sioux Falls, but the cost of living remains affordable, particularly within the housing market. Lansing experiences four distinct seasons, akin to the climate in Sioux Falls, and offers a blend of city life coupled with historical sites, parks, and local universities, making it an appealing option for those looking to balance their career with an engaging lifestyle.
Sioux Falls boasts a diverse range of healthcare facilities that have consistently sought the expertise of Medical Surgical Registered Nurses for per diem positions, ensuring that high-quality patient care is always within reach. Whether it’s bustling hospitals or specialized clinics, these organizations recognize the vital role that skilled RNs play in delivering essential services to the community.