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Permanent Nurse Practitioner Advanced Practice Jobs in South Carolina

Find Exciting Permanent Nurse Practitioner Jobs in South Carolina with AMN Healthcare

Are you a Nurse Practitioner Advanced Practice professional seeking permanent job opportunities in South Carolina? Look no further! AMN Healthcare is your gateway to a wide array of rewarding career options in the heart of South Carolina. With a total of 2 permanent Nurse Practitioner jobs currently available, our platform is your one-stop destination for your job search needs.

Competitive Salaries for Nurse Practitioner Professionals in South Carolina

When it comes to compensation, AMN Healthcare ensures that our opportunities are not just abundant but also lucrative. The pay rates for our current Nurse Practitioner Advanced Practice jobs in South Carolina range from $120k to $155k annually. Based on jobs placed in the last year, the average pay rate for Nurse Practitioner positions in was $130k per year. In fact, the average annual salary for Nurse Practitioner positions currently available as of Oct 10, 2026 stands at $134k per year.

Nurse Practitioner Salary Trends in South Carolina

We understand that staying informed about salary trends is essential when you’re considering your next career move. Based on historical data from the last year of posted Nurse Practitioner jobs in South Carolina, the average pay hovers around $130k per year. It’s worth noting that the highest paying job in South Carolina for a permanent Nurse Practitioner role in the last year reached $140k annually, highlighting the potential for growth in your career.

Flexible Start Dates in South Carolina to Suit Your Schedule

At AMN Healthcare, we prioritize your convenience. As of Oct 10, 2026, we offer Nurse Practitioner jobs in South Carolina with a range of starting dates, including Oct 23, 2026 (2 jobs). This flexibility allows you to plan your transition into a new position seamlessly, giving you the freedom to choose what works best for your schedule.

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Top Cities in South Carolina with Permanent Nurse Practitioner Jobs

AMN Healthcare currently has 2 permanent Nurse Practitioner positions available in the state of South Carolina. Search the most recent jobs below, or click the button below to view all jobs.

Highest Paying Jobs in South Carolina

AMN Healthcare currently has permanent Nurse Practitioner positions available in South Carolina.
permanent
Oncology Nurse Practitioner or Physician Assistant (NP/PA)
  • October 23, 2026
$120k to $155k
Yearly Pay*
A respected, physician-led oncology group in Hilton Head, SC, is seeking a Board-Certified Nurse Practitioner or Physician Assistant to join its growing outpatient team. This is a 100% ambulatory role with a strong existing patient base, top-tier facilities, and a focus on quality, community-based cancer care. Position Highlights •       Flexible Schedule opportunities  •       Balanced hematology and oncology mix •       Average 12-15 patients per day •       Modern infusion centers, on-site labs, imaging, and radiation oncology •       Minimal call (1:7 rotation, phone only) Compensation & Benefits •       5 weeks PTO + 7 paid holidays •       $2K CME stipend •       Comprehensive health, dental, vision, and 401(k) Why Hilton Head? Enjoy 12 miles of pristine beaches, world-class golf, and year-round outdoor living. Hilton Head offers the charm of a close-knit community with the amenities of a coastal resort—excellent schools, mild weather, and easy access to Savannah and Charleston. To learn more or to apply, please direct inquiries to Danielle Kriegl of AMN Healthcare at danielle.kriegl@amnhealthcare.com . Applicants should include a complete CV and a letter of interest outlining relevant experience.
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permanent
Pediatric Neurology Nurse Practitioner or Physician Assistant (NP/PA)
  • October 23, 2026
$125k to $135k
Yearly Pay*
The Medical University of South Carolina (MUSC) is seeking a Pediatric Advanced Practice Provider to join the Division of Pediatric Neurology within the Department of Pediatrics. This full-time outpatient opportunity offers the ability to care for children and adolescents in a collaborative academic environment while helping expand access to specialized pediatric neurology services. The ideal candidate will bring pediatric clinical experience, a team-oriented mindset, and a passion for improving the lives of pediatric patients and families. This position offers the opportunity to practice alongside experienced pediatric specialists while contributing to quality improvement, education, and clinical excellence. Opportunity Highlights
  • Full-time outpatient pediatric neurology practice
  • Monday-Friday schedule, 8 a.m. to 5 p.m.
  • Care for patients from birth through age 21
  • Academic environment within South Carolina's leading academic health system
  • Collaborative multidisciplinary pediatric neurology team
  • Opportunity to help grow and expand pediatric neurology services
  • Participate in quality improvement and clinical research initiatives
  • Potential to precept Advanced Practice Provider students
  • Evidence-based practice environment with strong physician collaboration
  • Located in one of the Southeast's most desirable coastal communities
Candidate Requirements
  • Completion of an accredited Physician Assistant program with licensure or eligibility for licensure as a Physician Assistant, or completion of an accredited Nurse Practitioner program with licensure or eligibility for licensure as an Advanced Practice Registered Nurse
  • Pediatric experience required
  • Pediatric neurology experience strongly preferred
  • Current Pediatric Advanced Life Support certification prior to start date
  • South Carolina licensure eligibility required
Community Information Charleston delivers an exceptional combination of coastal living, cultural amenities, academic opportunity, and year-round outdoor recreation. Frequently recognized as one of the most desirable places to live in the Southeast, Charleston offers beautiful beaches, a nationally recognized culinary scene, a thriving healthcare community, and a growing technology sector often referred to as "Silicon Harbor." Charleston also ranks among the top places to live in South Carolina and is known for its historic charm, walkable neighborhoods, and outstanding lifestyle amenities. (U.S. News & World Report, 2026, ; (AreaVibes, 2026, ; (Niche, 2026,
  • Ranked among the top places to live in South Carolina by U.S. News & World Report (2026)
  • Exceptional livability score with strong amenities, schools, and healthcare resources according to AreaVibes (2026)
  • Recognized among South Carolina's best communities for young professionals and families by Niche (2026)
To learn more, contact: Ben Moulton Senior Managing Consultant, AMN Healthcare ben.moulton@amnhealthcare.com 404-809-1897
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View all Jobs in South Carolina

Statistics on Nurse Practitioner Jobs in South Carolina

At AMN Healthcare, we try to provide you with the data you need to make a decision about working a Nurse Practitioner permanent job in South Carolina. We’ve compiled information about salary ranges and trends over the last 3 months, along with other important statistics about types of healthcare facilities offering work in South Carolina so you have the latest at your fingertips.

Salary Range

per year

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Frequently Asked Questions about Permanent Nurse Practitioner Jobs in South Carolina

How many Nurse Practitioner jobs are currently available in South Carolina?

As of Oct 10, 2026, AMN Healthcare currently has 2 exclusive permanent Nurse Practitioner job opportunities waiting for you in South Carolina.

What is the salary range for permanent Nurse Practitioner jobs in South Carolina?

The pay rates for the available Nurse Practitioner Advanced Practice jobs in South Carolina range from $120k to $155k per year, providing competitive compensation options.

What is the average annual salary for Nurse Practitioner positions in South Carolina?

As of Oct 10, 2026, the average annual salary based on 4 permanent Nurse Practitioner jobs in South Carolina is $135k yearly, ensuring you are fairly rewarded for your expertise.

Can you tell me about historical salary trends in South Carolina for permanent Nurse Practitioner positions?

Based on historical data from the last year, the average annual salary for permanent Nurse Practitioner jobs in South Carolina was $130k per year. The highest-paying position in South Carolina in the past year reached $140k annually, showcasing the potential for substantial earnings.

Are there flexible start dates available for these South Carolina Nurse Practitioner jobs?

Yes, as of Oct 10, 2026, AMN Healthcare offers permanent Nurse Practitioner Advanced Practice jobs in South Carolina with various starting dates to accommodate your schedule. Some options include a start date of Oct 23, 2026 (2 jobs).

Healthcare Facilities in South Carolina that Offer Nurse Practitioner Jobs

These are just examples of some of the healthcare facilities in and around the South Carolina area that have historically offered permanent jobs for Nurse Practitioner professionals.

AFC Urgent Care Boiling Springs
AFC Urgent Care Boiling Springs is a hospital located at 2746 Boiling Springs Road in Boiling Springs, SC, that includes an Urgent Care department. Physicians and advanced practice clinicians staff the site. As a hospital-based urgent care facility, it provides immediate evaluation and treatment for non-life-threatening injuries and illnesses delivered by physician and advanced practice clinician teams.
2746 Boiling Springs Road, Boiling Springs, SC 29316
Departments
Urgent Care
Hilton Head Hospital
Hilton Head Hospital is a hospital located at 25 Hospital Center Blvd in Hilton Head Island, SC. Onsite departments include CVOR and PCU, and the facility’s clinical staff categories include advanced practice clinicians, physicians, and nursing; as a hospital with a cardiovascular operating room and a progressive care unit, it supports surgical procedures and intermediate-level inpatient care.
25 Hospital Center Blvd, Hilton Head Island, SC 29926
Departments
PCU and CVOR
Shifts: 12 E and 12 N
MUSC Health – Florence Medical Center
MUSC Health – Florence Medical Center is a short-term acute care hospital located at 805 Pamplico Hwy., #. 100550 in Florence, SC, near the Nob Hill and Siesta Village neighborhoods. Clinical operations include emergency medicine, nocturnist coverage, internal medicine and cardiac services, with advanced practice clinicians and physicians on the medical staff. As a short-term acute care hospital staffed by physicians and advanced practice providers, the facility delivers emergency and inpatient medical management and round-the-clock physician-led coverage typical for this facility type.
805 PAMPLICO HWY., #. 100550, FLORENCE, SC 29505
Departments
Internal Medicine, ER, and Cardiac
MUSC Health – Orangeburg
MUSC Health – Orangeburg is a short-term acute care hospital located at 3000 Saint Matthews Rd in Orangeburg, SC, near the Spring Valley and Heatherwood neighborhoods. Departments include nocturnist coverage, pediatrics, hospitalist services and mammography, and the clinical staff includes advanced practice providers and physicians.
3000 Saint Matthews Rd, Orangeburg, SC 29118
Departments
Mammography and Hospitalist
MUSC Health Columbia Medical Center Northeast
MUSC Health Columbia Medical Center Northeast is a Short-Term Acute Care Hospital located at 120 Gateway Corporate Blvd in Columbia, SC, near Brickyard Village and Fairfield Arms. The facility lists a Pedi department and reports advanced practice clinicians and physicians among its clinical professions. Short-term acute care hospitals provide diagnosis, stabilization and short-term treatment of acute illness and injury, functions commonly performed by physicians and advanced practice providers.
120 Gateway Corporate Blvd, Columbia, SC 29203
Departments
Pedi
MUSC Health Kershaw Medical Center
MUSC Health Kershaw Medical Center is a short-term acute care hospital located at 1315 Roberts St in Camden, SC, near the Edgewood neighborhood. Clinical departments listed include Hospitalist and Pedi, and the medical staff categories noted are Physician and Advanced Practice. As a short-term acute care facility, it delivers acute inpatient and urgent medical services typically managed by hospitalists, pediatric clinicians, physicians and advanced practice clinicians.
1315 Roberts St, Camden, SC 29020
Departments
Hospitalist and Pedi
St Francis Downtown
St Francis Downtown is a short-term acute care hospital at 1 Saint Francis Dr in Greenville, SC, located near Mountain View Homes and University Ridge Homes. Departments include CVOR, vascular surgery, teleradiology, mammography, diagnostic radiology and oncology, and the medical staff includes physicians and advanced practice clinicians.
1 Saint Francis Dr, Greenville, SC 29601
Departments
Mammography, Teleradiology, CVOR, Oncology, and Diagnostic Radiology

Find Other Types of Nurse Practitioner Jobs in South Carolina

* Estimate of payments is intended for informational purposes and includes hourly wages, as well as reimbursements for meal & incidental expenses and housing expenses incurred on behalf of the Company. Please speak with a recruiter for additional details.