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Permanent Nurse Practitioner Advanced Practice Jobs in South Carolina

Find Exciting Permanent Nurse Practitioner Jobs in South Carolina with AMN Healthcare

Are you a Nurse Practitioner Advanced Practice professional seeking permanent job opportunities in South Carolina? Look no further! AMN Healthcare is your gateway to a wide array of rewarding career options in the heart of South Carolina. With a total of 2 permanent Nurse Practitioner jobs currently available, our platform is your one-stop destination for your job search needs.

Competitive Salaries for Nurse Practitioner Professionals in South Carolina

When it comes to compensation, AMN Healthcare ensures that our opportunities are not just abundant but also lucrative. The pay rates for our current Nurse Practitioner Advanced Practice jobs in South Carolina range from $120k to $155k annually. Based on jobs placed in the last year, the average pay rate for Nurse Practitioner positions in was $130k per year. In fact, the average annual salary for Nurse Practitioner positions currently available as of Oct 22, 2026 stands at $134k per year.

Nurse Practitioner Salary Trends in South Carolina

We understand that staying informed about salary trends is essential when you’re considering your next career move. Based on historical data from the last year of posted Nurse Practitioner jobs in South Carolina, the average pay hovers around $130k per year. It’s worth noting that the highest paying job in South Carolina for a permanent Nurse Practitioner role in the last year reached $140k annually, highlighting the potential for growth in your career.

Flexible Start Dates in South Carolina to Suit Your Schedule

At AMN Healthcare, we prioritize your convenience. As of Oct 22, 2026, we offer Nurse Practitioner jobs in South Carolina with a range of starting dates, including Nov 5, 2026 (2 jobs). This flexibility allows you to plan your transition into a new position seamlessly, giving you the freedom to choose what works best for your schedule.

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Top Cities in South Carolina with Permanent Nurse Practitioner Jobs

AMN Healthcare currently has 2 permanent Nurse Practitioner positions available in the state of South Carolina. Search the most recent jobs below, or click the button below to view all jobs.

Highest Paying Jobs in South Carolina

AMN Healthcare currently has permanent Nurse Practitioner positions available in South Carolina.
permanent
Oncology Nurse Practitioner or Physician Assistant (NP/PA)
  • November 5, 2026
$120k to $155k
Yearly Pay*
A respected, physician-led oncology group in Hilton Head, SC, is seeking a Board-Certified Nurse Practitioner or Physician Assistant to join its growing outpatient team. This is a 100% ambulatory role with a strong existing patient base, top-tier facilities, and a focus on quality, community-based cancer care. Position Highlights •       Flexible Schedule opportunities  •       Balanced hematology and oncology mix •       Average 12-15 patients per day •       Modern infusion centers, on-site labs, imaging, and radiation oncology •       Minimal call (1:7 rotation, phone only) Compensation & Benefits •       5 weeks PTO + 7 paid holidays •       $2K CME stipend •       Comprehensive health, dental, vision, and 401(k) Why Hilton Head? Enjoy 12 miles of pristine beaches, world-class golf, and year-round outdoor living. Hilton Head offers the charm of a close-knit community with the amenities of a coastal resort—excellent schools, mild weather, and easy access to Savannah and Charleston. To learn more or to apply, please direct inquiries to Danielle Kriegl of AMN Healthcare at danielle.kriegl@amnhealthcare.com . Applicants should include a complete CV and a letter of interest outlining relevant experience. ?#LI-KR2
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permanent
Pediatric Neurology Nurse Practitioner or Physician Assistant (NP/PA)
  • November 5, 2026
$125k to $135k
Yearly Pay*
The Medical University of South Carolina (MUSC) is seeking a Pediatric Advanced Practice Provider to join the Division of Pediatric Neurology within the Department of Pediatrics. This full-time outpatient opportunity offers the ability to care for children and adolescents in a collaborative academic environment while helping expand access to specialized pediatric neurology services. The ideal candidate will bring pediatric clinical experience, a team-oriented mindset, and a passion for improving the lives of pediatric patients and families. This position offers the opportunity to practice alongside experienced pediatric specialists while contributing to quality improvement, education, and clinical excellence. Opportunity Highlights
  • Full-time outpatient pediatric neurology practice
  • Monday-Friday schedule, 8 a.m. to 5 p.m.
  • Care for patients from birth through age 21
  • Academic environment within South Carolina's leading academic health system
  • Collaborative multidisciplinary pediatric neurology team
  • Opportunity to help grow and expand pediatric neurology services
  • Participate in quality improvement and clinical research initiatives
  • Potential to precept Advanced Practice Provider students
  • Evidence-based practice environment with strong physician collaboration
  • Located in one of the Southeast's most desirable coastal communities
Candidate Requirements
  • Completion of an accredited Physician Assistant program with licensure or eligibility for licensure as a Physician Assistant, or completion of an accredited Nurse Practitioner program with licensure or eligibility for licensure as an Advanced Practice Registered Nurse
  • Pediatric experience required
  • Pediatric neurology experience strongly preferred
  • Current Pediatric Advanced Life Support certification prior to start date
  • South Carolina licensure eligibility required
Community Information Charleston delivers an exceptional combination of coastal living, cultural amenities, academic opportunity, and year-round outdoor recreation. Frequently recognized as one of the most desirable places to live in the Southeast, Charleston offers beautiful beaches, a nationally recognized culinary scene, a thriving healthcare community, and a growing technology sector often referred to as "Silicon Harbor." Charleston also ranks among the top places to live in South Carolina and is known for its historic charm, walkable neighborhoods, and outstanding lifestyle amenities. (U.S. News & World Report, 2026, ; (AreaVibes, 2026, ; (Niche, 2026,
  • Ranked among the top places to live in South Carolina by U.S. News & World Report (2026)
  • Exceptional livability score with strong amenities, schools, and healthcare resources according to AreaVibes (2026)
  • Recognized among South Carolina's best communities for young professionals and families by Niche (2026)
To learn more, contact: Ben Moulton Senior Managing Consultant, AMN Healthcare ben.moulton@amnhealthcare.com 404-809-1897
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View all Jobs in South Carolina

Statistics on Nurse Practitioner Jobs in South Carolina

At AMN Healthcare, we try to provide you with the data you need to make a decision about working a Nurse Practitioner permanent job in South Carolina. We’ve compiled information about salary ranges and trends over the last 3 months, along with other important statistics about types of healthcare facilities offering work in South Carolina so you have the latest at your fingertips.

Salary Range

per year

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Frequently Asked Questions about Permanent Nurse Practitioner Jobs in South Carolina

How many Nurse Practitioner jobs are currently available in South Carolina?

As of Oct 22, 2026, AMN Healthcare currently has 2 exclusive permanent Nurse Practitioner job opportunities waiting for you in South Carolina.

What is the salary range for permanent Nurse Practitioner jobs in South Carolina?

The pay rates for the available Nurse Practitioner Advanced Practice jobs in South Carolina range from $120k to $155k per year, providing competitive compensation options.

What is the average annual salary for Nurse Practitioner positions in South Carolina?

As of Oct 22, 2026, the average annual salary based on 4 permanent Nurse Practitioner jobs in South Carolina is $135k yearly, ensuring you are fairly rewarded for your expertise.

Can you tell me about historical salary trends in South Carolina for permanent Nurse Practitioner positions?

Based on historical data from the last year, the average annual salary for permanent Nurse Practitioner jobs in South Carolina was $130k per year. The highest-paying position in South Carolina in the past year reached $140k annually, showcasing the potential for substantial earnings.

Are there flexible start dates available for these South Carolina Nurse Practitioner jobs?

Yes, as of Oct 22, 2026, AMN Healthcare offers permanent Nurse Practitioner Advanced Practice jobs in South Carolina with various starting dates to accommodate your schedule. Some options include a start date of Nov 5, 2026 (2 jobs).

How can I find out when new jobs open in South Carolina?

New positions in South Carolina are added as healthcare facilities post them, so openings can change quickly. Download the AMN Passport app or create an AMN Healthcare profile to set job alerts, save searches, and get notified when roles that match your experience become available. An AMN recruiter can also let you know about upcoming opportunities.

Healthcare Facilities in South Carolina that Offer Nurse Practitioner Jobs

These are just examples of some of the healthcare facilities in and around the South Carolina area that have historically offered permanent jobs for Nurse Practitioner professionals.

AFC Urgent Care Boiling Springs
AFC Urgent Care Boiling Springs is a hospital located at 2746 Boiling Springs Road in Boiling Springs, SC, with an urgent care department. As a hospital-based urgent care setting staffed by physicians and advanced practice providers, it serves the role of providing unscheduled evaluation and treatment for acute, non-emergent conditions.
2746 Boiling Springs Road, Boiling Springs, SC 29316
Departments
Urgent Care
Hilton Head Hospital
Hilton Head Hospital is a short-term acute care hospital located at 25 Hospital Center Blvd, Hilton Head Island, SC. Its clinical departments include a broad mix of surgical and perioperative services (OR, CVOR, PACU, sterile processing), emergency care and critical care units (ER, ICU, PCU, NICU), maternal and pediatric services (Labor & Delivery, postpartum, pediatrics), and diagnostic services such as laboratory, computed tomography, nuclear medicine and echocardiography, with additional specialties including vascular and medical-surgical units. The facility employs physicians, advanced practice providers, nursing staff and allied health professionals.
25 Hospital Center Blvd, Hilton Head Island, SC 29926
Departments
ER, Laboratory, Echo, OR, Computed Tomography, Labor & Delivery, MS, Pedi, PCU, ICU, NICU, Postpartum, CVOR, Adult, Vascular, Acute, Nuclear Medicine, PACU, and Sterile Processor
Shifts: 8 D, 10 D, 10 E, 10 N, 12 D, 12 E, and 12 N
Durations: 6 wks, 8 wks, 12 wks, 13 wks, 14 wks, 26 wks, and 118 wks
MUSC Health – Florence Medical Center
MUSC Health – Florence Medical Center is a short-term acute care hospital at 805 Pamplico Hwy., #. 100550 in Florence, SC, near Nob Hill and Siesta Village. Departments include Internal Medicine, ER and Cardiac, and the facility’s clinical staff is composed of advanced practice providers and physicians.
805 PAMPLICO HWY., #. 100550, FLORENCE, SC 29505
Departments
Internal Medicine, ER, and Cardiac
MUSC Health – Orangeburg
MUSC Health – Orangeburg is a short-term acute care hospital located at 3000 Saint Matthews Rd in Orangeburg, SC, near the Spring Valley and Heatherwood neighborhoods. The facility lists Hospitalist and Mammography departments and notes physicians and advanced practice clinicians among its clinical professions. Short-term acute care hospitals with hospitalist services and mammography typically provide inpatient medical management and diagnostic breast imaging supported by physician and advanced practice teams.
3000 Saint Matthews Rd, Orangeburg, SC 29118
Departments
Hospitalist and Mammography
MUSC Health Columbia Medical Center Northeast
MUSC Health Columbia Medical Center Northeast is a short-term acute care hospital located at 120 Gateway Corporate Blvd in Columbia, SC, near Brickyard Village and Fairfield Arms. Clinical departments include Pedi, and the medical staff comprises physicians and advanced practice providers. As a short-term acute care hospital staffed by physicians and advanced practice clinicians, it provides hospital-based diagnostic, medical, and procedural care typical for this facility type.
120 Gateway Corporate Blvd, Columbia, SC 29203
Departments
Pedi
MUSC Health Kershaw Medical Center
MUSC Health Kershaw Medical Center is a short-term acute care hospital located at 1315 Roberts St in Camden, SC, near the Edgewood neighborhood. Clinical departments include Pedi and Hospitalist services, and the facility staffs physicians and advanced practice clinicians. As a short-term acute care hospital, it provides acute inpatient and stabilization services delivered through physician-led and advanced practice provider teams.
1315 Roberts St, Camden, SC 29020
Departments
Pedi and Hospitalist
St Francis Downtown
St Francis Downtown is a short-term acute care hospital at 1 Saint Francis Dr in Greenville, SC, near Mountain View Homes and University Ridge Homes. Departments include Diagnostic Radiology with mammography and teleradiology capability, a cardiovascular operating room (CVOR), and Oncology. The medical staff includes physicians and advanced practice clinicians.
1 Saint Francis Dr, Greenville, SC 29601
Departments
Diagnostic Radiology, Teleradiology, CVOR, Mammography, and Oncology
Trident Medical Center
TJC
For-Profit
Trident Medical Center is a short-term acute care hospital located at 9330 Medical Plaza Dr in Charleston, SC, near the Huntington Woods and Parkshire neighborhoods; it was established in 1975, is for-profit, has 497 beds and is accredited by TJC. Clinical capacity includes 22 operating rooms, two cardiac catheterization labs, six endoscopy rooms and a wide range of diagnostic and therapeutic services such as CT, MRI, PET, nuclear medicine, extracorporeal shockwave lithotripsy, dialysis and comprehensive perioperative and rehabilitation services. Departments span emergency and designated trauma services, multiple critical care units (CVICU, CCU, medical/surgical ICU, pediatric ICU), obstetrics and neonatal nursery, cardiothoracic and vascular surgery, interventional and diagnostic radiology, inpatient and outpatient psychiatry, burn care and CARF inpatient rehabilitation, among others. The medical staff includes physicians, advanced practice providers, nursing, allied health and support services, the facility hosts allopathic, osteopathic, dental, podiatric and other residency programs, and operates with a workforce equivalent to approximately 2,217 full-time positions.
9330 Medical Plaza Dr, CHARLESTON, SC 29406
497 certified beds 22 operating rooms Established 1975
SERVICES
Pharmacy
Acute Renal Dialysis
Anesthesia
Audiology
Chemotherapy
Departments
Magnetic Resonance Imaging, Surgical, Dialysis, Hospitalist, OB/GYN, Interventional Radiology, Radiology, Vascular, Acute, CVOR, PACU, OR, Psych, ICU, Computed Tomography, PCU, Echo, EEG, Rehab, Cath Lab, Case Manager, EP Lab, Positron Emission Tomography, Telemetry, CVICU, MS, Diagnostic, Nuclear Medicine, Trauma, Critical Care, Adult Inpatient Psychiatric, Burn Care Unit, Cardiac Catheterization Lab, Open Heart / Cardiothoracic Surgery, CARF Inpatient Rehabilitation, Coronary Care Unit (CCU), Designated Trauma Center, Emergency Department, Emergency Psychiatric, Gerontological Specialty, Inpatient Surgical, Intensive Care Unit (Medical/Surgical ICU), Neonatal Nursery, Neurosurgical, Obstetrics (OB/L&D), Orthopedic Surgery (Hospital), Outpatient Psychiatric, Outpatient Rehabilitation, Outpatient Surgery, Pediatric, Pediatric ICU, Reconstructive Surgery, Surgical ICU, Psychiatric Unit, and Rehabilitation Unit
Shifts: 8 D, 8 E, 8 N, 9 D, 10 D, 10 E, 10 N, 12 D, 12 E, and 12 N
Durations: 6 wks, 8 wks, 11 wks, 12 wks, 13 wks, 15 wks, and 26 wks

Find Other Types of Nurse Practitioner Jobs in South Carolina

* Estimate of payments is intended for informational purposes and includes hourly wages, as well as reimbursements for meal & incidental expenses and housing expenses incurred on behalf of the Company. Please speak with a recruiter for additional details.