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Registered Nurse Per Diem Jobs in Santa Ana, CA

Information About Per Diem RN Positions in Santa Ana

At AMN Healthcare, we understand that nursing professionals seeking per diem Registered Nurse jobs in Santa Ana desire flexibility, variety, and support throughout their careers. With over 40 years as a staffing leader, we proudly connect more than 10,000 healthcare workers annually with exceptional opportunities in diverse specialties such as Medical Surgical, Emergency Room, Intensive Care Unit, Labor & Delivery, and Home Health, among many others. Our personalized guidance and commitment to your professional development ensure that you find the right position that fits your unique skills and lifestyle. Whether you’re interested in working in a fast-paced telemetry unit or seeking a rewarding role in pediatric care, AMN Healthcare is here to empower your nursing journey with support, resources, and access to a vast network of healthcare facilities. Join us, and discover your next opportunity in nursing today!

Research High-Paying Registered Nurse Opportunities in Santa Ana, CA

A few of the highest paying Registered Nurse jobs available in Santa Ana, CA include:

AMN Healthcare is currently offering 4 per diem Registered Nurse job opportunities in Santa Ana, CA, with hourly pay ranging from $43 to $49 and an average of $46 per hour. These positions span a variety of specialties including Intensive Care Unit RN and Long Term Acute Care Registered Nurse. With start dates available as early as 5/24/26 (4 jobs), professionals can quickly secure a role that aligns with their career goals.

Jobs are available in zip codes 92706, with additional opportunities in nearby cities such as Fountain Valley (5.5 miles), Irvine (5.9 miles), and Anaheim (6.8 miles). Whether you’re looking to explore new locations or gain diverse clinical experience, we’re here to help you find the perfect per diem Registered Nurse job. Just click Apply Now and we’ll match you with a recruiter to help you find your next Registered Nurse position in or near Santa Ana!

Registered Nurse Facilities and Duties in Santa Ana

Santa Ana, California, offers a diverse range of opportunities for Registered Nurses across various specialties and healthcare settings, reflecting the dynamic landscape of modern nursing. From bustling medical-surgical units and telemetry departments to high-stakes emergency rooms and intensive care units, RNs can engage in the fast-paced environment of critical care or the more structured atmosphere of progressive care and rehabilitation. Specialized roles such as those in labor and delivery, neonatal intensive care, and oncology allow nurses to make profound impacts on patients’ lives at key life moments. Additionally, opportunities exist in outpatient clinics, home health, and long-term acute care facilities where nurses focus on patient education and chronic condition management. Others may find roles in advanced areas such as interventional radiology, catheterization labs, or even clinical education and nursing administration, contributing to the cultivation of future nursing talent. With a commitment to comprehensive patient care and a supportive community, Santa Ana provides a vibrant backdrop for nursing professionals to thrive and advance their careers in diverse and meaningful ways.

Reasons RN Professionals Like to Work a Per Diem Job in Santa Ana, California

As a Registered Nurse, opting for a per diem job in Santa Ana, California, offers not only professional flexibility but also the allure of an exciting lifestyle in a vibrant city. With its warm Mediterranean climate, you can enjoy sunny days year-round, making outdoor leisure activities a staple of your daily life. Santa Ana boasts lively neighborhoods like the Historic District, known for its charming architecture and artistic vibe, and the trendy South Coast Metro area, offering an array of dining and shopping options. Beyond work, immerse yourself in the city’s culture by visiting the renowned Bowers Museum, exploring local parks, or enjoying the diverse array of festivals throughout the year. With its perfect blend of work-life balance, community engagement, and scenic surroundings, Santa Ana is an ideal choice for RNs seeking flexibility without sacrificing quality of life.

Find Your Ideal Per Diem Registered Nurse Jobs in Santa Ana

Explore a variety of per diem Registered Nurse opportunities available in the vibrant city of Santa Ana, where your skills and dedication can make a real difference. Browse through the listings below to find the perfect job that aligns with your career goals and lifestyle preferences!

per diem
Intensive Care Unit Nurse (ICU RN)
  • Santa Ana, California – 92706
  • 12 D,
  • May 24, 2026
$46 to $49
Hourly Pay*
ICU RN's provide highly specialized care to patients who suffer from a serious injury or illness. ICU RN’s need to keep watch over people whose condition may undergo rapid changes as well as care for those who are often too ill to care for themselves in even the most basic capacity. ICU RN’s work in the ICU unit of a hospital, sometimes called Critical Care. ICU RN’s may be asked to float to PCU or TeleEducation/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
  • ACLS and CRRT are often required
*** ACLS, BLS (AHA)  must be included in packet – Recent 1 yr exp Has specific Scion template to use for submission
per diem
Intensive Care Unit Nurse (ICU RN)
  • Santa Ana, California – 92706
  • 12 N,
  • May 24, 2026
$46 to $49
Hourly Pay*
ICU RN's provide highly specialized care to patients who suffer from a serious injury or illness. ICU RN’s need to keep watch over people whose condition may undergo rapid changes as well as care for those who are often too ill to care for themselves in even the most basic capacity. ICU RN’s work in the ICU unit of a hospital, sometimes called Critical Care. ICU RN’s may be asked to float to PCU or TeleEducation/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
  • ACLS and CRRT are often required
*** ACLS, BLS (AHA)  must be included in packet – Recent 1 yr exp Has specific Scion template to use for submission
per diem
Long Term Care Nurse (SNF/LTC RN)
  • Santa Ana, California – 92706
  • 12 D,
  • May 24, 2026
$43 to $46
Hourly Pay*
Long Term Care RN services can be necessary over the short term for rehabilitation from an illness or injury, or they may be required over the long term for patients who need care on a frequent or around-the-clock basis due to a chronic medical condition. Examples of skilled nursing services include wound care, intravenous (IV) therapy, injections, physical therapy, and monitoring of vital signs and medical equipment. LTC RN’s can work in a variety of settings includes camps, clinics, schools, and ambulatory care centers but typically work at Skilled Nursing FacilitiesEducation/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
*** LTAC/Telemetry  2-5 yrs exp;  ACLS/BLS (AHA) included in packet – Has specific Scion template to use for submission
per diem
Long Term Care Nurse (SNF/LTC RN)
  • Santa Ana, California – 92706
  • 12 N,
  • May 24, 2026
$43 to $46
Hourly Pay*
Long Term Care RN services can be necessary over the short term for rehabilitation from an illness or injury, or they may be required over the long term for patients who need care on a frequent or around-the-clock basis due to a chronic medical condition. Examples of skilled nursing services include wound care, intravenous (IV) therapy, injections, physical therapy, and monitoring of vital signs and medical equipment. LTC RN’s can work in a variety of settings includes camps, clinics, schools, and ambulatory care centers but typically work at Skilled Nursing FacilitiesEducation/Requirements:
  • Bachelor of Science in Nursing (BSN): 4-Year Education 
  • Associates Degree in Nursing (ADN): 2-Year Education 
  • You must earn an ADN or BSN degree and pass the NCLEX to apply for a license as a RN. 
  • RN‘s can only work with an active state license.
*** LTAC/Telemetry  2-5 yrs exp;  ACLS/BLS (AHA) included in packet – Has specific Scion template to use for submission
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Job Market Statistics for Per Diem Registered Nurse Professionals in Santa Ana

As you explore the data presented below, you’ll gain valuable insights into the per diem Registered Nurse job market in Santa Ana. Our comprehensive statistics capture crucial information on average pay trends over the past three months, as well as insights into the average, minimum, and maximum pay for nursing roles over the last year. This data is designed to empower you with a clear understanding of the compensation landscape, helping you to make informed career decisions in this vibrant healthcare hub.

In addition to pay trends, the accompanying charts also highlight the diversity and volume of healthcare facilities in Santa Ana that are actively seeking skilled RNs. By examining these statistics, you can better assess your opportunities and navigate the competitive job market more effectively. Whether you’re considering a new per diem position or simply wish to stay updated on market conditions, this information serves as a vital resource in your career journey.

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Frequently Asked Questions about Per Diem RN Jobs near Santa Ana, CA

What is the average pay for a Per Diem RN job in Santa Ana, California?

The average hourly pay for a Per Diem Registered Nurse job in Santa Ana, California is approximately $46 per hour for Medical Surgical RN, Telemetry Registered Nurse, and Emergency Room RN. This data was last updated on May 10, 2026.

What is the highest hourly pay for a Per Diem Registered Nurse job in Santa Ana?

The highest hourly pay for a Registered Nurse Per Diem job in Santa Ana is $49 per hour for a Skilled Registered Nurse. This data was last updated on May 10, 2026.

What types of experience are most commonly required for a Per Diem Registered Nurse job in Santa Ana?

Per diem Registered Nurse positions in Santa Ana typically require candidates to have a valid California RN license and previous clinical experience in acute care settings. Additionally, familiarity with electronic health records and strong communication skills are often sought after to ensure effective collaboration with healthcare teams.

What types of job opportunities are typically available for RN Per Diem positions in Santa Ana?

Registered Nurse professionals seeking Per Diem positions in Santa Ana can find opportunities in a variety of job types, including per diem and travel roles, including per diem and travel roles. These positions are available in specialized fields such as Intensive Care Unit and Long Term Acute Care, offering flexibility and career growth in diverse healthcare settings.

What types of healthcare facilities in Santa Ana typically offer Per Diem positions for Registered Nurse professionals?

In Santa Ana, per diem positions for Registered Nurse professionals in Medical Surgical, Telemetry, and Emergency Room settings are commonly available at acute care hospitals and specialty clinics. Additionally, larger healthcare systems often provide flexible staffing opportunities, catering to the varying needs of the community.

What types of specialties are common for a Registered Nurse professional working a Per Diem job in Santa Ana, California?

Common specialties for Registered Nurses working per diem jobs in Santa Ana, California typically include acute care, emergency medicine, and critical care. Additionally, many RNs may specialize in areas like pediatric nursing, labor and delivery, or surgical services, depending on local healthcare facility needs. The flexibility of per diem roles often allows nurses to explore various specialties across different settings. Overall, demand fluctuates based on the region’s healthcare landscape and patient populations.

What are some keys reasons a Per Diem Registered Nurse professional might consider seeking a Medical Surgical, Telemetry, and Emergency Room job in Santa Ana?

Per diem Registered Nurses might seek jobs in Santa Ana due to the city’s diverse healthcare facilities and a growing demand for nursing professionals driven by its expanding population. Additionally, the appealing southern California climate and vibrant local culture can enhance their overall work-life balance while providing enriching experiences outside of work.

What are some most popular areas in Santa Ana a Per Diem RN professionals would prefer to work and live?

Per diem Registered Nurse professionals in Santa Ana often prefer areas like the downtown district for its proximity to healthcare facilities and vibrant urban lifestyle. Additionally, neighborhoods such as South Coast Metro and Floral Park are popular for their access to amenities and community feel. These areas provide a balance of work opportunities and quality living environments, appealing to the diverse needs of nursing professionals.

What important factors should a Per Diem Registered Nurse professionals consider when evaluating a new position?

Per diem Registered Nurse professionals should consider the pay rate and benefits associated with the new position, as these directly impact financial stability and job satisfaction. Additionally, factors such as the facility’s location, work environment, and flexibility of scheduling play a crucial role in ensuring a good fit. Lastly, evaluating the type of units or specialties available can help ensure that the position aligns with their professional skills and interests.

Which US Cities Offer Job Opportunities Similar to Santa Ana for Registered Nurse Professionals

One city that parallels Santa Ana, California, for Registered Nurse professionals is Tucson, Arizona. Tucson offers a comparable cost of living, often lower than that of Santa Ana, with affordable housing options ranging from single-family homes to apartments. The healthcare environment features several major hospitals and healthcare systems that provide ample opportunities in Medical Surgical, Telemetry, and Emergency Room nursing. The climate is warm and sunny with a desert landscape, similar to Orange County, presenting a range of outdoor activities and cultural events, including the annual Tucson Gem, Mineral & Fossil Showcase.

Another city to consider is San Antonio, Texas. Known for its diverse population and rich cultural heritage, San Antonio has a lower cost of living than Santa Ana, making housing accessible for Registered Nurses starting in their careers. The city is home to a robust healthcare system with numerous hospitals and specialty care facilities, presenting opportunities in various nursing specialties. The climate is warm with humid summers and mild winters, and the vibrant lifestyle includes local attractions like the historic Alamo, outdoor festivals, and a lively restaurant scene that reflects the city’s Tex-Mex culture.

Orlando, Florida, is another city that offers a similar experience for nursing professionals. With a cost of living that is moderate compared to Santa Ana, Orlando features a variety of housing options, from suburban neighborhoods to urban condominiums. There are several large hospitals and healthcare institutions, providing career opportunities in all nursing specialties, including emergency care. The climate is predominantly warm and humid, offering outdoor leisure activities year-round. Known for its entertainment offerings, Orlando also has a lively social scene, including theme parks, cultural festivals, and recreational opportunities.

One more city that fits the criteria is Raleigh, North Carolina. The cost of living in Raleigh is moderate, often more affordable than in Santa Ana, with a housing market that provides diverse options including suburban areas and modern apartments. The local healthcare network is expanding rapidly, giving Registered Nurses a range of environments to work in, especially in critical care and emergency sectors. The climate features four distinct seasons, which is different from the California coast but still quite mild, allowing for various outdoor activities throughout the year. Raleigh’s lifestyle is vibrant, with numerous cultural events, restaurants, and a strong community focus.

Finally, consider Las Vegas, Nevada, which shares a vibrant healthcare sector with ample nursing opportunities in areas such as Medical Surgical and Emergency Room care. The cost of living in Las Vegas is generally lower than in Santa Ana, with various housing options from affordable homes to high-rise apartments. The desert climate is hot and dry, offering outdoor recreation opportunities for those who enjoy the sun. With its renowned entertainment scene that includes a plethora of shows, dining options, and nightlife, Las Vegas provides a dynamic and exciting lifestyle for healthcare professionals seeking both work and play.

Santa Ana Healthcare Facilities With a History of Hiring Per Diem Registered Nurse Professionals

Santa Ana boasts a variety of healthcare facilities renowned for their commitment to patient care and frequent hiring of Registered Nurse professionals for per diem positions in Medical Surgical, Telemetry, and Emergency Room departments. These dynamic opportunities not only provide flexibility for nursing staff but also allow them to thrive in a bustling community dedicated to improving health outcomes.

Kaiser Permanente – Orange County Irvine Medical Center
Shifts
12 D and 12 N
Departments
Emergency Room Physician Assistant, ER, Labor & Delivery Registered Nurse, OB/GYN Radiologic Technology, Post Anesthesia Care Unit, and Skilled RN
Address
6640 Alton Parkway
Irvine, CA 92618
Nearby Neighborhoods
East Irvine (92650), The Meadows (92604), Como (92604), Kathryn (92620), Frances (92620)
Kaiser Permanente Anaheim Medical Center
Shifts
12 D and 12 N
Departments
Family Care Nurse Practitioner, Labor & Delivery Registered Nurse, Psychology Physician, and Skilled RN
Address
3440 E La Palma Ave.
Anaheim, CA 92806
Nearby Neighborhoods
Rio Vista Mobile Home Estates (92899), Peralta Hills (92817), Palm Lodge Mobile Home Estates (92816), Yorba (92811), Anaheim Royal Mobile Home Park (92816)
UCI – Fountain Valley Regional Hospital and Medical Center
Shifts
8 D, 12 D, and 12 N
Job Durations
13 wks
Departments
Acute Care Physical Therapy, Acute Care Social Worker, and RN Case Manager
Address
17100 Euclid St
Fountain Valley, CA 92708
Nearby Neighborhoods
Rancho La Siesta Mobile Home Park (92708), Fountain Valley Mobile Home Estates (92708)
UCI – Placentia Linda Hospital
Shifts
12 D and 12 N
Departments
Emergency Room RN and Telemetry RN
Address
1301 N Rose Dr
Placentia, CA 92870
Nearby Neighborhoods
Del Cerro Mobile Home Estates (92811), Hacienda Mobile Home Park (92870)
* Estimate of payments is intended for informational purposes and includes hourly wages, as well as reimbursements for meal & incidental expenses and housing expenses incurred on behalf of the Company. Please speak with a recruiter for additional details.